Transglutaminase 2 undergoes a large conformational change upon activation.

Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathogenesis of celiac sprue. Although vertebrate transglutaminases have been...

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Autores principales: Daniel M Pinkas, Pavel Strop, Axel T Brunger, Chaitan Khosla
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2007
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Acceso en línea:https://doaj.org/article/1807f4db44564b6e8e5268aebe2b45fa
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