Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance

The fungal pathogen Candida glabrata readily acquires resistance to multiple types of antifungal drugs. Here, Healey et al. show that C. glabrataclinical isolates often carry mutations in a gene involved in DNA mismatch repair, and this is associated with increased propensity to develop antifungal r...

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Autores principales:	Kelley R. Healey, Yanan Zhao, Winder B. Perez, Shawn R. Lockhart, Jack D. Sobel, Dimitrios Farmakiotis, Dimitrios P. Kontoyiannis, Dominique Sanglard, Saad J. Taj-Aldeen, Barbara D. Alexander, Cristina Jimenez-Ortigosa, Erika Shor, David S. Perlin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1815c031c89a4873a9003da52493606b
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spelling	oai:doaj.org-article:1815c031c89a4873a9003da52493606b2021-12-02T17:32:23ZPrevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance10.1038/ncomms111282041-1723https://doaj.org/article/1815c031c89a4873a9003da52493606b2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11128https://doaj.org/toc/2041-1723The fungal pathogen Candida glabrata readily acquires resistance to multiple types of antifungal drugs. Here, Healey et al. show that C. glabrataclinical isolates often carry mutations in a gene involved in DNA mismatch repair, and this is associated with increased propensity to develop antifungal resistance.Kelley R. HealeyYanan ZhaoWinder B. PerezShawn R. LockhartJack D. SobelDimitrios FarmakiotisDimitrios P. KontoyiannisDominique SanglardSaad J. Taj-AldeenBarbara D. AlexanderCristina Jimenez-OrtigosaErika ShorDavid S. PerlinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kelley R. Healey Yanan Zhao Winder B. Perez Shawn R. Lockhart Jack D. Sobel Dimitrios Farmakiotis Dimitrios P. Kontoyiannis Dominique Sanglard Saad J. Taj-Aldeen Barbara D. Alexander Cristina Jimenez-Ortigosa Erika Shor David S. Perlin Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance
description	The fungal pathogen Candida glabrata readily acquires resistance to multiple types of antifungal drugs. Here, Healey et al. show that C. glabrataclinical isolates often carry mutations in a gene involved in DNA mismatch repair, and this is associated with increased propensity to develop antifungal resistance.
format	article
author	Kelley R. Healey Yanan Zhao Winder B. Perez Shawn R. Lockhart Jack D. Sobel Dimitrios Farmakiotis Dimitrios P. Kontoyiannis Dominique Sanglard Saad J. Taj-Aldeen Barbara D. Alexander Cristina Jimenez-Ortigosa Erika Shor David S. Perlin
author_facet	Kelley R. Healey Yanan Zhao Winder B. Perez Shawn R. Lockhart Jack D. Sobel Dimitrios Farmakiotis Dimitrios P. Kontoyiannis Dominique Sanglard Saad J. Taj-Aldeen Barbara D. Alexander Cristina Jimenez-Ortigosa Erika Shor David S. Perlin
author_sort	Kelley R. Healey
title	Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance
title_short	Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance
title_full	Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance
title_fullStr	Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance
title_full_unstemmed	Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance
title_sort	prevalent mutator genotype identified in fungal pathogen candida glabrata promotes multi-drug resistance
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1815c031c89a4873a9003da52493606b
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Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance

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