Treatment With the CSF1R Antagonist GW2580, Sensitizes Microglia to Reactive Oxygen Species

Microglia activation and proliferation are hallmarks of many neurodegenerative disorders and may contribute to disease pathogenesis. Neurons actively regulate microglia survival and function, in part by secreting the microglia mitogen interleukin (IL)-34. Both IL-34 and colony stimulating factor (CS...

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Autores principales: Katiria Soto-Diaz, Mario Vailati-Riboni, Allison Y. Louie, Daniel B. McKim, H. Rex Gaskins, Rodney W. Johnson, Andrew J. Steelman
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/185334dc51354d5985830fbbc29456a3
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