Characterization of eukaryotic DNA N6-methyladenine by a highly sensitive restriction enzyme-assisted sequencing

DNA N6-methyladenine is prevalent in prokaryotes, and is recently also detected in eukaryotes such as roundworm and fly. Here, Luo et al. report a DpnI-assisted base resolution method that detects 6mA genome-wide with nanograms of input DNA and lower sequencing depth than the previous restriction en...

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Autores principales: Guan-Zheng Luo, Fang Wang, Xiaocheng Weng, Kai Chen, Ziyang Hao, Miao Yu, Xin Deng, Jianzhao Liu, Chuan He
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/18aa662e4dcb4b83b7acf84a73004a33
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