Unique Habitual Food Intakes in the Gut Microbiota Cluster Associated with Type 2 Diabetes Mellitus
This cross-sectional study aimed to clarify the characteristic gut microbiota of Japanese patients with type 2 diabetes (T2DM) using t-distributed stochastic neighbor embedding analysis and the k-means method and to clarify the relationship with background data, including dietary habits. The gut mic...
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MDPI AG
2021
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oai:doaj.org-article:18b9f204e3ea478c98c2190f0e10b62b2021-11-25T18:34:23ZUnique Habitual Food Intakes in the Gut Microbiota Cluster Associated with Type 2 Diabetes Mellitus10.3390/nu131138162072-6643https://doaj.org/article/18b9f204e3ea478c98c2190f0e10b62b2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3816https://doaj.org/toc/2072-6643This cross-sectional study aimed to clarify the characteristic gut microbiota of Japanese patients with type 2 diabetes (T2DM) using t-distributed stochastic neighbor embedding analysis and the k-means method and to clarify the relationship with background data, including dietary habits. The gut microbiota data of 383 patients with T2DM and 114 individuals without T2DM were classified into red, blue, green, and yellow groups. The proportions of patients with T2DM in the red, blue, green, and yellow groups was 86.8% (112/129), 69.8% (81/116), 76.3% (90/118), and 74.6% (100/134), respectively; the red group had the highest prevalence of T2DM. There were no intergroup differences in sex, age, or body mass index. The red group had higher percentages of the <i>Bifidobacterium</i> and <i>Lactobacillus</i> genera and lower percentages of the <i>Blautia</i> and <i>Phascolarctobacterium</i> genera. Higher proportions of patients with T2DM in the red group used α-glucosidase inhibitors and glinide medications and had a low intake of fermented soybean foods, including miso soup, than those in the other groups. The gut microbiota pattern of the red group may indicate characteristic changes in the gut microbiota associated with T2DM in Japan. These results also suggest that certain diabetes drugs and fermented foods may be involved in this change. Further studies are needed to confirm the relationships among traditional dietary habits, the gut microbiota, and T2DM in Japan.Yuriko KondoYoshitaka HashimotoMasahide HamaguchiShinto AndoAyumi KajiRyosuke SakaiRyo InoueSaori KashiwagiKatsura MizushimaKazuhiko UchiyamaTomohisa TakagiYuji NaitoMichiaki FukuiMDPI AGarticledietary habitsfermented foodsgut microbiotatype 2 diabetes mellitusNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3816, p 3816 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
dietary habits fermented foods gut microbiota type 2 diabetes mellitus Nutrition. Foods and food supply TX341-641 |
| spellingShingle |
dietary habits fermented foods gut microbiota type 2 diabetes mellitus Nutrition. Foods and food supply TX341-641 Yuriko Kondo Yoshitaka Hashimoto Masahide Hamaguchi Shinto Ando Ayumi Kaji Ryosuke Sakai Ryo Inoue Saori Kashiwagi Katsura Mizushima Kazuhiko Uchiyama Tomohisa Takagi Yuji Naito Michiaki Fukui Unique Habitual Food Intakes in the Gut Microbiota Cluster Associated with Type 2 Diabetes Mellitus |
| description |
This cross-sectional study aimed to clarify the characteristic gut microbiota of Japanese patients with type 2 diabetes (T2DM) using t-distributed stochastic neighbor embedding analysis and the k-means method and to clarify the relationship with background data, including dietary habits. The gut microbiota data of 383 patients with T2DM and 114 individuals without T2DM were classified into red, blue, green, and yellow groups. The proportions of patients with T2DM in the red, blue, green, and yellow groups was 86.8% (112/129), 69.8% (81/116), 76.3% (90/118), and 74.6% (100/134), respectively; the red group had the highest prevalence of T2DM. There were no intergroup differences in sex, age, or body mass index. The red group had higher percentages of the <i>Bifidobacterium</i> and <i>Lactobacillus</i> genera and lower percentages of the <i>Blautia</i> and <i>Phascolarctobacterium</i> genera. Higher proportions of patients with T2DM in the red group used α-glucosidase inhibitors and glinide medications and had a low intake of fermented soybean foods, including miso soup, than those in the other groups. The gut microbiota pattern of the red group may indicate characteristic changes in the gut microbiota associated with T2DM in Japan. These results also suggest that certain diabetes drugs and fermented foods may be involved in this change. Further studies are needed to confirm the relationships among traditional dietary habits, the gut microbiota, and T2DM in Japan. |
| format |
article |
| author |
Yuriko Kondo Yoshitaka Hashimoto Masahide Hamaguchi Shinto Ando Ayumi Kaji Ryosuke Sakai Ryo Inoue Saori Kashiwagi Katsura Mizushima Kazuhiko Uchiyama Tomohisa Takagi Yuji Naito Michiaki Fukui |
| author_facet |
Yuriko Kondo Yoshitaka Hashimoto Masahide Hamaguchi Shinto Ando Ayumi Kaji Ryosuke Sakai Ryo Inoue Saori Kashiwagi Katsura Mizushima Kazuhiko Uchiyama Tomohisa Takagi Yuji Naito Michiaki Fukui |
| author_sort |
Yuriko Kondo |
| title |
Unique Habitual Food Intakes in the Gut Microbiota Cluster Associated with Type 2 Diabetes Mellitus |
| title_short |
Unique Habitual Food Intakes in the Gut Microbiota Cluster Associated with Type 2 Diabetes Mellitus |
| title_full |
Unique Habitual Food Intakes in the Gut Microbiota Cluster Associated with Type 2 Diabetes Mellitus |
| title_fullStr |
Unique Habitual Food Intakes in the Gut Microbiota Cluster Associated with Type 2 Diabetes Mellitus |
| title_full_unstemmed |
Unique Habitual Food Intakes in the Gut Microbiota Cluster Associated with Type 2 Diabetes Mellitus |
| title_sort |
unique habitual food intakes in the gut microbiota cluster associated with type 2 diabetes mellitus |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/18b9f204e3ea478c98c2190f0e10b62b |
| work_keys_str_mv |
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