Structural basis for delta cell paracrine regulation in pancreatic islets

Structural basis for delta cell paracrine regulation in pancreatic islets

Pancreatic islets are composed of alpha-, beta-, as well as delta-cells and appropriate regulation of glucose homeostasis relies on auto- and paracrine cellular communication. Here, the authors study the role of delta-cell filopodia in this context by employing optogenetic and calcium imaging approa...

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Main Authors: Rafael Arrojo e Drigo, Stefan Jacob, Concha F. García-Prieto, Xiaofeng Zheng, Masahiro Fukuda, Hoa Tran Thi Nhu, Olga Stelmashenko, Flavia Letícia Martins Peçanha, Rayner Rodriguez-Diaz, Eric Bushong, Thomas Deerinck, Sebastien Phan, Yusuf Ali, Ingo Leibiger, Minni Chua, Thomas Boudier, Sang-Ho Song, Martin Graf, George J. Augustine, Mark H. Ellisman, Per-Olof Berggren
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
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Online Access:https://doaj.org/article/18bb2e2d712b47329b5a77a1642cf62e
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https://doaj.org/article/18bb2e2d712b47329b5a77a1642cf62e

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