Structural basis for delta cell paracrine regulation in pancreatic islets

Pancreatic islets are composed of alpha-, beta-, as well as delta-cells and appropriate regulation of glucose homeostasis relies on auto- and paracrine cellular communication. Here, the authors study the role of delta-cell filopodia in this context by employing optogenetic and calcium imaging approa...

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Autores principales:	Rafael Arrojo e Drigo, Stefan Jacob, Concha F. García-Prieto, Xiaofeng Zheng, Masahiro Fukuda, Hoa Tran Thi Nhu, Olga Stelmashenko, Flavia Letícia Martins Peçanha, Rayner Rodriguez-Diaz, Eric Bushong, Thomas Deerinck, Sebastien Phan, Yusuf Ali, Ingo Leibiger, Minni Chua, Thomas Boudier, Sang-Ho Song, Martin Graf, George J. Augustine, Mark H. Ellisman, Per-Olof Berggren
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/18bb2e2d712b47329b5a77a1642cf62e
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spelling	oai:doaj.org-article:18bb2e2d712b47329b5a77a1642cf62e2021-12-02T14:38:37ZStructural basis for delta cell paracrine regulation in pancreatic islets10.1038/s41467-019-11517-x2041-1723https://doaj.org/article/18bb2e2d712b47329b5a77a1642cf62e2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11517-xhttps://doaj.org/toc/2041-1723Pancreatic islets are composed of alpha-, beta-, as well as delta-cells and appropriate regulation of glucose homeostasis relies on auto- and paracrine cellular communication. Here, the authors study the role of delta-cell filopodia in this context by employing optogenetic and calcium imaging approaches.Rafael Arrojo e DrigoStefan JacobConcha F. García-PrietoXiaofeng ZhengMasahiro FukudaHoa Tran Thi NhuOlga StelmashenkoFlavia Letícia Martins PeçanhaRayner Rodriguez-DiazEric BushongThomas DeerinckSebastien PhanYusuf AliIngo LeibigerMinni ChuaThomas BoudierSang-Ho SongMartin GrafGeorge J. AugustineMark H. EllismanPer-Olof BerggrenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rafael Arrojo e Drigo Stefan Jacob Concha F. García-Prieto Xiaofeng Zheng Masahiro Fukuda Hoa Tran Thi Nhu Olga Stelmashenko Flavia Letícia Martins Peçanha Rayner Rodriguez-Diaz Eric Bushong Thomas Deerinck Sebastien Phan Yusuf Ali Ingo Leibiger Minni Chua Thomas Boudier Sang-Ho Song Martin Graf George J. Augustine Mark H. Ellisman Per-Olof Berggren Structural basis for delta cell paracrine regulation in pancreatic islets
description	Pancreatic islets are composed of alpha-, beta-, as well as delta-cells and appropriate regulation of glucose homeostasis relies on auto- and paracrine cellular communication. Here, the authors study the role of delta-cell filopodia in this context by employing optogenetic and calcium imaging approaches.
format	article
author	Rafael Arrojo e Drigo Stefan Jacob Concha F. García-Prieto Xiaofeng Zheng Masahiro Fukuda Hoa Tran Thi Nhu Olga Stelmashenko Flavia Letícia Martins Peçanha Rayner Rodriguez-Diaz Eric Bushong Thomas Deerinck Sebastien Phan Yusuf Ali Ingo Leibiger Minni Chua Thomas Boudier Sang-Ho Song Martin Graf George J. Augustine Mark H. Ellisman Per-Olof Berggren
author_facet	Rafael Arrojo e Drigo Stefan Jacob Concha F. García-Prieto Xiaofeng Zheng Masahiro Fukuda Hoa Tran Thi Nhu Olga Stelmashenko Flavia Letícia Martins Peçanha Rayner Rodriguez-Diaz Eric Bushong Thomas Deerinck Sebastien Phan Yusuf Ali Ingo Leibiger Minni Chua Thomas Boudier Sang-Ho Song Martin Graf George J. Augustine Mark H. Ellisman Per-Olof Berggren
author_sort	Rafael Arrojo e Drigo
title	Structural basis for delta cell paracrine regulation in pancreatic islets
title_short	Structural basis for delta cell paracrine regulation in pancreatic islets
title_full	Structural basis for delta cell paracrine regulation in pancreatic islets
title_fullStr	Structural basis for delta cell paracrine regulation in pancreatic islets
title_full_unstemmed	Structural basis for delta cell paracrine regulation in pancreatic islets
title_sort	structural basis for delta cell paracrine regulation in pancreatic islets
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/18bb2e2d712b47329b5a77a1642cf62e
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Structural basis for delta cell paracrine regulation in pancreatic islets

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