COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report

COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report

ABSTRACT: This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) fo...

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Bibliographic Details
Main Authors: Wayne F. Leung, Samuel Chorlton, John Tyson, Ghada N. Al-Rawahi, Agatha N. Jassem, Natalie Prystajecky, Shazia Masud, Gregory D. Deans, Michael G. Chapman, Yazdan Mirzanejad, Melanie C.M. Murray, Patrick H.P. Wong
Format: article
Language:EN
Published: Elsevier 2022
Subjects:
SARS-CoV-2
Immunocompromised
Sequencing
Mutation
Viral culture
Case report
Infectious and parasitic diseases
RC109-216
Online Access:https://doaj.org/article/18e2e86402434a7bbe3b88b65ecdaad9
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Summary:ABSTRACT: This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations.

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