The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma

The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma

Expression of NKG2D immunoreceptor ligands on tumour cells is believed to inhibit tumour growth through engaging NKG2D-expressing immune cells. Here, the authors show that in a model of liver cancer the NKG2D/NKG2D-ligand pathway can also promote tumour formation by sustaining an inflammatory enviro...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Sam Sheppard, Joana Guedes, Anna Mroz, Anastasia-Maria Zavitsanou, Hiromi Kudo, Stephen M. Rothery, Panagiotis Angelopoulos, Robert Goldin, Nadia Guerra
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/19101936214342739334b5deafccc5f2
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:19101936214342739334b5deafccc5f2
record_format dspace
spelling oai:doaj.org-article:19101936214342739334b5deafccc5f22021-12-02T15:37:02ZThe immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma10.1038/ncomms139302041-1723https://doaj.org/article/19101936214342739334b5deafccc5f22017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13930https://doaj.org/toc/2041-1723Expression of NKG2D immunoreceptor ligands on tumour cells is believed to inhibit tumour growth through engaging NKG2D-expressing immune cells. Here, the authors show that in a model of liver cancer the NKG2D/NKG2D-ligand pathway can also promote tumour formation by sustaining an inflammatory environment.Sam SheppardJoana GuedesAnna MrozAnastasia-Maria ZavitsanouHiromi KudoStephen M. RotheryPanagiotis AngelopoulosRobert GoldinNadia GuerraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sam Sheppard
Joana Guedes
Anna Mroz
Anastasia-Maria Zavitsanou
Hiromi Kudo
Stephen M. Rothery
Panagiotis Angelopoulos
Robert Goldin
Nadia Guerra
The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma
description Expression of NKG2D immunoreceptor ligands on tumour cells is believed to inhibit tumour growth through engaging NKG2D-expressing immune cells. Here, the authors show that in a model of liver cancer the NKG2D/NKG2D-ligand pathway can also promote tumour formation by sustaining an inflammatory environment.
format article
author Sam Sheppard
Joana Guedes
Anna Mroz
Anastasia-Maria Zavitsanou
Hiromi Kudo
Stephen M. Rothery
Panagiotis Angelopoulos
Robert Goldin
Nadia Guerra
author_facet Sam Sheppard
Joana Guedes
Anna Mroz
Anastasia-Maria Zavitsanou
Hiromi Kudo
Stephen M. Rothery
Panagiotis Angelopoulos
Robert Goldin
Nadia Guerra
author_sort Sam Sheppard
title The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma
title_short The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma
title_full The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma
title_fullStr The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma
title_full_unstemmed The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma
title_sort immunoreceptor nkg2d promotes tumour growth in a model of hepatocellular carcinoma
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/19101936214342739334b5deafccc5f2
work_keys_str_mv AT samsheppard theimmunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT joanaguedes theimmunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT annamroz theimmunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT anastasiamariazavitsanou theimmunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT hiromikudo theimmunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT stephenmrothery theimmunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT panagiotisangelopoulos theimmunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT robertgoldin theimmunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT nadiaguerra theimmunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT samsheppard immunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT joanaguedes immunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT annamroz immunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT anastasiamariazavitsanou immunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT hiromikudo immunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT stephenmrothery immunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT panagiotisangelopoulos immunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT robertgoldin immunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
AT nadiaguerra immunoreceptornkg2dpromotestumourgrowthinamodelofhepatocellularcarcinoma
_version_ 1718386217597272064

Ejemplares similares