Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway

Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway

ABSTRACT Viral infections induce proinflammatory signaling cascades and inflammatory cytokine production, which is precisely regulated for host benefits. In the current study, we unravel a previously unappreciated role of nonmuscle myosin heavy chain IIA (NMHC-IIA) as a negative regulator in inflamm...

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Bibliographic Details
Main Authors: Yingqi Liu, Rui Li, Xin-xin Chen, Yubao Zhi, Ruiguang Deng, En-min Zhou, Songlin Qiao, Gaiping Zhang
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
DAP12
NMHC-IIA
negative modulation
proinflammatory responses
sialic acids
sialylated RNA virus
Microbiology
QR1-502
Online Access:https://doaj.org/article/1910a67c3a7b4f89a5ee6602a974ea91
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https://doaj.org/article/1910a67c3a7b4f89a5ee6602a974ea91

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