Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas
Gliomas are tumors often associated with epigenetics-related gene deregulation. Here the authors reveal an atlas of active enhancers and promoters in benign and malignant gliomas by performing whole-genome mapping of chromatin accessibility, histone modifications, DNA methylation patterns and transc...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/19342f80dced49aba9a14fb218e8e058 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:19342f80dced49aba9a14fb218e8e058 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:19342f80dced49aba9a14fb218e8e0582021-12-02T17:40:33ZMapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas10.1038/s41467-021-23922-22041-1723https://doaj.org/article/19342f80dced49aba9a14fb218e8e0582021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23922-2https://doaj.org/toc/2041-1723Gliomas are tumors often associated with epigenetics-related gene deregulation. Here the authors reveal an atlas of active enhancers and promoters in benign and malignant gliomas by performing whole-genome mapping of chromatin accessibility, histone modifications, DNA methylation patterns and transcriptome analysis simultaneously in multiple tumor samples.Karolina StępniakMagdalena A. MachnickaJakub MieczkowskiAnna MacioszekBartosz WojtaśBartłomiej GielniewskiKatarzyna PoleszakMalgorzata PeryczSylwia K. KrólRafał GuzikMichał J. DąbrowskiMichał DramińskiMarta JardanowskaIlona GrabowiczAgata DziedzicHanna KranasKarolina SienkiewiczKlev DiamantiKatarzyna KotulskaWiesława GrajkowskaMarcin RoszkowskiTomasz CzernickiAndrzej MarchelJan KomorowskiBozena KaminskaBartek WilczyńskiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Karolina Stępniak Magdalena A. Machnicka Jakub Mieczkowski Anna Macioszek Bartosz Wojtaś Bartłomiej Gielniewski Katarzyna Poleszak Malgorzata Perycz Sylwia K. Król Rafał Guzik Michał J. Dąbrowski Michał Dramiński Marta Jardanowska Ilona Grabowicz Agata Dziedzic Hanna Kranas Karolina Sienkiewicz Klev Diamanti Katarzyna Kotulska Wiesława Grajkowska Marcin Roszkowski Tomasz Czernicki Andrzej Marchel Jan Komorowski Bozena Kaminska Bartek Wilczyński Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas |
| description |
Gliomas are tumors often associated with epigenetics-related gene deregulation. Here the authors reveal an atlas of active enhancers and promoters in benign and malignant gliomas by performing whole-genome mapping of chromatin accessibility, histone modifications, DNA methylation patterns and transcriptome analysis simultaneously in multiple tumor samples. |
| format |
article |
| author |
Karolina Stępniak Magdalena A. Machnicka Jakub Mieczkowski Anna Macioszek Bartosz Wojtaś Bartłomiej Gielniewski Katarzyna Poleszak Malgorzata Perycz Sylwia K. Król Rafał Guzik Michał J. Dąbrowski Michał Dramiński Marta Jardanowska Ilona Grabowicz Agata Dziedzic Hanna Kranas Karolina Sienkiewicz Klev Diamanti Katarzyna Kotulska Wiesława Grajkowska Marcin Roszkowski Tomasz Czernicki Andrzej Marchel Jan Komorowski Bozena Kaminska Bartek Wilczyński |
| author_facet |
Karolina Stępniak Magdalena A. Machnicka Jakub Mieczkowski Anna Macioszek Bartosz Wojtaś Bartłomiej Gielniewski Katarzyna Poleszak Malgorzata Perycz Sylwia K. Król Rafał Guzik Michał J. Dąbrowski Michał Dramiński Marta Jardanowska Ilona Grabowicz Agata Dziedzic Hanna Kranas Karolina Sienkiewicz Klev Diamanti Katarzyna Kotulska Wiesława Grajkowska Marcin Roszkowski Tomasz Czernicki Andrzej Marchel Jan Komorowski Bozena Kaminska Bartek Wilczyński |
| author_sort |
Karolina Stępniak |
| title |
Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas |
| title_short |
Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas |
| title_full |
Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas |
| title_fullStr |
Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas |
| title_full_unstemmed |
Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas |
| title_sort |
mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/19342f80dced49aba9a14fb218e8e058 |
| work_keys_str_mv |
AT karolinastepniak mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT magdalenaamachnicka mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT jakubmieczkowski mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT annamacioszek mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT bartoszwojtas mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT bartłomiejgielniewski mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT katarzynapoleszak mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT malgorzataperycz mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT sylwiakkrol mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT rafałguzik mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT michałjdabrowski mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT michałdraminski mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT martajardanowska mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT ilonagrabowicz mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT agatadziedzic mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT hannakranas mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT karolinasienkiewicz mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT klevdiamanti mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT katarzynakotulska mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT wiesławagrajkowska mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT marcinroszkowski mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT tomaszczernicki mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT andrzejmarchel mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT jankomorowski mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT bozenakaminska mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas AT bartekwilczynski mappingchromatinaccessibilityandactiveregulatoryelementsrevealspathologicalmechanismsinhumangliomas |
| _version_ |
1718379749381767168 |