TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22

Abstract The adaptor protein TNF receptor associated factor (TRAF) 3 is required for effective TCR signaling and normal T cell effector functions, and associates with the CD3/CD28 complex upon activation. To determine how TRAF3 promotes proximal TCR signaling, we studied TRAF3-deficient mouse and hu...

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Autores principales: Alicia M. Wallis, Ellie C. Wallace, Bruce S. Hostager, Zuoan Yi, Jon C. D. Houtman, Gail A. Bishop
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/193ddd2d1b1a4ac4ac05b3cd822eef66
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