TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22

TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22

Abstract The adaptor protein TNF receptor associated factor (TRAF) 3 is required for effective TCR signaling and normal T cell effector functions, and associates with the CD3/CD28 complex upon activation. To determine how TRAF3 promotes proximal TCR signaling, we studied TRAF3-deficient mouse and hu...

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Autores principales: Alicia M. Wallis, Ellie C. Wallace, Bruce S. Hostager, Zuoan Yi, Jon C. D. Houtman, Gail A. Bishop
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/193ddd2d1b1a4ac4ac05b3cd822eef66
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