Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci

Genomic polymorphisms affect the epigenome, which in turn influences how epigenome- and genome-wide analysis are interpreted. Here, the authors characterise allelic differences in DNA methylation driven by obligatory or facilitative genetic effects, which may affect disease-related loci.

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Autores principales:	Christopher G. Bell, Fei Gao, Wei Yuan, Leonie Roos, Richard J. Acton, Yudong Xia, Jordana Bell, Kirsten Ward, Massimo Mangino, Pirro G. Hysi, Jun Wang, Timothy D. Spector
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/193f30fb3ee44bea8996117919657ad9
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spelling	oai:doaj.org-article:193f30fb3ee44bea8996117919657ad92021-12-02T16:49:53ZObligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci10.1038/s41467-017-01586-12041-1723https://doaj.org/article/193f30fb3ee44bea8996117919657ad92018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01586-1https://doaj.org/toc/2041-1723Genomic polymorphisms affect the epigenome, which in turn influences how epigenome- and genome-wide analysis are interpreted. Here, the authors characterise allelic differences in DNA methylation driven by obligatory or facilitative genetic effects, which may affect disease-related loci.Christopher G. BellFei GaoWei YuanLeonie RoosRichard J. ActonYudong XiaJordana BellKirsten WardMassimo ManginoPirro G. HysiJun WangTimothy D. SpectorNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher G. Bell Fei Gao Wei Yuan Leonie Roos Richard J. Acton Yudong Xia Jordana Bell Kirsten Ward Massimo Mangino Pirro G. Hysi Jun Wang Timothy D. Spector Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci
description	Genomic polymorphisms affect the epigenome, which in turn influences how epigenome- and genome-wide analysis are interpreted. Here, the authors characterise allelic differences in DNA methylation driven by obligatory or facilitative genetic effects, which may affect disease-related loci.
format	article
author	Christopher G. Bell Fei Gao Wei Yuan Leonie Roos Richard J. Acton Yudong Xia Jordana Bell Kirsten Ward Massimo Mangino Pirro G. Hysi Jun Wang Timothy D. Spector
author_facet	Christopher G. Bell Fei Gao Wei Yuan Leonie Roos Richard J. Acton Yudong Xia Jordana Bell Kirsten Ward Massimo Mangino Pirro G. Hysi Jun Wang Timothy D. Spector
author_sort	Christopher G. Bell
title	Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci
title_short	Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci
title_full	Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci
title_fullStr	Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci
title_full_unstemmed	Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci
title_sort	obligatory and facilitative allelic variation in the dna methylome within common disease-associated loci
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/193f30fb3ee44bea8996117919657ad9
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Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci

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