A ruthenium-based 5-fluorouracil complex with enhanced cytotoxicity and apoptosis induction action in HCT116 cells

Abstract Combination of multifunctionalities into one compound is a rational strategy in medicinal chemical design, and have often been used with metallodrug-based compounds. In the present study, we synthesized a novel ruthenium-based 5-fluorouracil complex [Ru(5-FU)(PPh3)2(bipy)]PF6 (PPh3 = triphe...

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Autores principales: Valdenizia Rodrigues Silva, Rodrigo S. Corrêa, Luciano de Souza Santos, Milena Botelho Pereira Soares, Alzir Azevedo Batista, Daniel Pereira Bezerra
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/1946f744303c44fa9ceac3daed6ca3af
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