Analysis of cancer genomes reveals basic features of human aging and its role in cancer development

Somatic mutations are associated with disease, including cancer. Here, the authors analyse cancer genomic data and show that somatic mutations increase with age and that cancer incidence lags 15 years behind this increase, later in life, mutation and cancer incidence are reduced.

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Autores principales:	Dmitriy I. Podolskiy, Alexei V. Lobanov, Gregory V. Kryukov, Vadim N. Gladyshev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/194930feb5f74d6d8e7f05ca0400f466
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spelling	oai:doaj.org-article:194930feb5f74d6d8e7f05ca0400f4662021-12-02T15:35:00ZAnalysis of cancer genomes reveals basic features of human aging and its role in cancer development10.1038/ncomms121572041-1723https://doaj.org/article/194930feb5f74d6d8e7f05ca0400f4662016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12157https://doaj.org/toc/2041-1723Somatic mutations are associated with disease, including cancer. Here, the authors analyse cancer genomic data and show that somatic mutations increase with age and that cancer incidence lags 15 years behind this increase, later in life, mutation and cancer incidence are reduced.Dmitriy I. PodolskiyAlexei V. LobanovGregory V. KryukovVadim N. GladyshevNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dmitriy I. Podolskiy Alexei V. Lobanov Gregory V. Kryukov Vadim N. Gladyshev Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
description	Somatic mutations are associated with disease, including cancer. Here, the authors analyse cancer genomic data and show that somatic mutations increase with age and that cancer incidence lags 15 years behind this increase, later in life, mutation and cancer incidence are reduced.
format	article
author	Dmitriy I. Podolskiy Alexei V. Lobanov Gregory V. Kryukov Vadim N. Gladyshev
author_facet	Dmitriy I. Podolskiy Alexei V. Lobanov Gregory V. Kryukov Vadim N. Gladyshev
author_sort	Dmitriy I. Podolskiy
title	Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
title_short	Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
title_full	Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
title_fullStr	Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
title_full_unstemmed	Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
title_sort	analysis of cancer genomes reveals basic features of human aging and its role in cancer development
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/194930feb5f74d6d8e7f05ca0400f466
work_keys_str_mv	AT dmitriyipodolskiy analysisofcancergenomesrevealsbasicfeaturesofhumanaginganditsroleincancerdevelopment AT alexeivlobanov analysisofcancergenomesrevealsbasicfeaturesofhumanaginganditsroleincancerdevelopment AT gregoryvkryukov analysisofcancergenomesrevealsbasicfeaturesofhumanaginganditsroleincancerdevelopment AT vadimngladyshev analysisofcancergenomesrevealsbasicfeaturesofhumanaginganditsroleincancerdevelopment
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Analysis of cancer genomes reveals basic features of human aging and its role in cancer development

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