Analysis of cancer genomes reveals basic features of human aging and its role in cancer development

Somatic mutations are associated with disease, including cancer. Here, the authors analyse cancer genomic data and show that somatic mutations increase with age and that cancer incidence lags 15 years behind this increase, later in life, mutation and cancer incidence are reduced.

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Autores principales: Dmitriy I. Podolskiy, Alexei V. Lobanov, Gregory V. Kryukov, Vadim N. Gladyshev
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/194930feb5f74d6d8e7f05ca0400f466
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spelling oai:doaj.org-article:194930feb5f74d6d8e7f05ca0400f4662021-12-02T15:35:00ZAnalysis of cancer genomes reveals basic features of human aging and its role in cancer development10.1038/ncomms121572041-1723https://doaj.org/article/194930feb5f74d6d8e7f05ca0400f4662016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12157https://doaj.org/toc/2041-1723Somatic mutations are associated with disease, including cancer. Here, the authors analyse cancer genomic data and show that somatic mutations increase with age and that cancer incidence lags 15 years behind this increase, later in life, mutation and cancer incidence are reduced.Dmitriy I. PodolskiyAlexei V. LobanovGregory V. KryukovVadim N. GladyshevNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dmitriy I. Podolskiy
Alexei V. Lobanov
Gregory V. Kryukov
Vadim N. Gladyshev
Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
description Somatic mutations are associated with disease, including cancer. Here, the authors analyse cancer genomic data and show that somatic mutations increase with age and that cancer incidence lags 15 years behind this increase, later in life, mutation and cancer incidence are reduced.
format article
author Dmitriy I. Podolskiy
Alexei V. Lobanov
Gregory V. Kryukov
Vadim N. Gladyshev
author_facet Dmitriy I. Podolskiy
Alexei V. Lobanov
Gregory V. Kryukov
Vadim N. Gladyshev
author_sort Dmitriy I. Podolskiy
title Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
title_short Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
title_full Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
title_fullStr Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
title_full_unstemmed Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
title_sort analysis of cancer genomes reveals basic features of human aging and its role in cancer development
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/194930feb5f74d6d8e7f05ca0400f466
work_keys_str_mv AT dmitriyipodolskiy analysisofcancergenomesrevealsbasicfeaturesofhumanaginganditsroleincancerdevelopment
AT alexeivlobanov analysisofcancergenomesrevealsbasicfeaturesofhumanaginganditsroleincancerdevelopment
AT gregoryvkryukov analysisofcancergenomesrevealsbasicfeaturesofhumanaginganditsroleincancerdevelopment
AT vadimngladyshev analysisofcancergenomesrevealsbasicfeaturesofhumanaginganditsroleincancerdevelopment
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