Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
Somatic mutations are associated with disease, including cancer. Here, the authors analyse cancer genomic data and show that somatic mutations increase with age and that cancer incidence lags 15 years behind this increase, later in life, mutation and cancer incidence are reduced.
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Nature Portfolio
2016
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oai:doaj.org-article:194930feb5f74d6d8e7f05ca0400f4662021-12-02T15:35:00ZAnalysis of cancer genomes reveals basic features of human aging and its role in cancer development10.1038/ncomms121572041-1723https://doaj.org/article/194930feb5f74d6d8e7f05ca0400f4662016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12157https://doaj.org/toc/2041-1723Somatic mutations are associated with disease, including cancer. Here, the authors analyse cancer genomic data and show that somatic mutations increase with age and that cancer incidence lags 15 years behind this increase, later in life, mutation and cancer incidence are reduced.Dmitriy I. PodolskiyAlexei V. LobanovGregory V. KryukovVadim N. GladyshevNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
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Science Q Dmitriy I. Podolskiy Alexei V. Lobanov Gregory V. Kryukov Vadim N. Gladyshev Analysis of cancer genomes reveals basic features of human aging and its role in cancer development |
description |
Somatic mutations are associated with disease, including cancer. Here, the authors analyse cancer genomic data and show that somatic mutations increase with age and that cancer incidence lags 15 years behind this increase, later in life, mutation and cancer incidence are reduced. |
format |
article |
author |
Dmitriy I. Podolskiy Alexei V. Lobanov Gregory V. Kryukov Vadim N. Gladyshev |
author_facet |
Dmitriy I. Podolskiy Alexei V. Lobanov Gregory V. Kryukov Vadim N. Gladyshev |
author_sort |
Dmitriy I. Podolskiy |
title |
Analysis of cancer genomes reveals basic features of human aging and its role in cancer development |
title_short |
Analysis of cancer genomes reveals basic features of human aging and its role in cancer development |
title_full |
Analysis of cancer genomes reveals basic features of human aging and its role in cancer development |
title_fullStr |
Analysis of cancer genomes reveals basic features of human aging and its role in cancer development |
title_full_unstemmed |
Analysis of cancer genomes reveals basic features of human aging and its role in cancer development |
title_sort |
analysis of cancer genomes reveals basic features of human aging and its role in cancer development |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/194930feb5f74d6d8e7f05ca0400f466 |
work_keys_str_mv |
AT dmitriyipodolskiy analysisofcancergenomesrevealsbasicfeaturesofhumanaginganditsroleincancerdevelopment AT alexeivlobanov analysisofcancergenomesrevealsbasicfeaturesofhumanaginganditsroleincancerdevelopment AT gregoryvkryukov analysisofcancergenomesrevealsbasicfeaturesofhumanaginganditsroleincancerdevelopment AT vadimngladyshev analysisofcancergenomesrevealsbasicfeaturesofhumanaginganditsroleincancerdevelopment |
_version_ |
1718386642694176768 |