Beyond the List: Bioagent-Agnostic Signatures Could Enable a More Flexible and Resilient Biodefense Posture Than an Approach Based on Priority Agent Lists Alone

As of 2021, the biothreat policy and research communities organize their efforts around lists of priority agents, which elides consideration of novel pathogens and biotoxins. For example, the Select Agents and Toxins list is composed of agents that historic biological warfare programs had weaponized...

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Autores principales:	Owen P. Leiser, Errett C. Hobbs, Amy C. Sims, George W. Korch, Karen L. Taylor
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bioagent-agnostic biodefense interactome biosurveillance select agents countermeasures Medicine R
Acceso en línea:	https://doaj.org/article/194b7ddd01d94df2a72cd3a108d38336
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spelling	oai:doaj.org-article:194b7ddd01d94df2a72cd3a108d383362021-11-25T18:38:43ZBeyond the List: Bioagent-Agnostic Signatures Could Enable a More Flexible and Resilient Biodefense Posture Than an Approach Based on Priority Agent Lists Alone10.3390/pathogens101114972076-0817https://doaj.org/article/194b7ddd01d94df2a72cd3a108d383362021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1497https://doaj.org/toc/2076-0817As of 2021, the biothreat policy and research communities organize their efforts around lists of priority agents, which elides consideration of novel pathogens and biotoxins. For example, the Select Agents and Toxins list is composed of agents that historic biological warfare programs had weaponized or that have previously caused great harm during natural outbreaks. Similarly, lists of priority agents promulgated by the World Health Organization and the National Institute of Allergy and Infectious Diseases are composed of previously known pathogens and biotoxins. To fill this gap, we argue that the research/scientific and biodefense/biosecurity communities should categorize agents based on how they impact their hosts to augment current list-based paradigms. Specifically, we propose integrating the results of multi-omics studies to identify bioagent-agnostic signatures (BASs) of disease—namely, patterns of biomarkers that accurately and reproducibly predict the impacts of infection or intoxication without prior knowledge of the causative agent. Here, we highlight three pathways that investigators might exploit as sources of signals to construct BASs and their applicability to this framework. The research community will need to forge robust interdisciplinary teams to surmount substantial experimental, technical, and data analytic challenges that stand in the way of our long-term vision. However, if successful, our functionality-based BAS model could present a means to more effectively surveil for and treat known and novel agents alike.Owen P. LeiserErrett C. HobbsAmy C. SimsGeorge W. KorchKaren L. TaylorMDPI AGarticlebioagent-agnosticbiodefenseinteractomebiosurveillanceselect agentscountermeasuresMedicineRENPathogens, Vol 10, Iss 1497, p 1497 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bioagent-agnostic biodefense interactome biosurveillance select agents countermeasures Medicine R
spellingShingle	bioagent-agnostic biodefense interactome biosurveillance select agents countermeasures Medicine R Owen P. Leiser Errett C. Hobbs Amy C. Sims George W. Korch Karen L. Taylor Beyond the List: Bioagent-Agnostic Signatures Could Enable a More Flexible and Resilient Biodefense Posture Than an Approach Based on Priority Agent Lists Alone
description	As of 2021, the biothreat policy and research communities organize their efforts around lists of priority agents, which elides consideration of novel pathogens and biotoxins. For example, the Select Agents and Toxins list is composed of agents that historic biological warfare programs had weaponized or that have previously caused great harm during natural outbreaks. Similarly, lists of priority agents promulgated by the World Health Organization and the National Institute of Allergy and Infectious Diseases are composed of previously known pathogens and biotoxins. To fill this gap, we argue that the research/scientific and biodefense/biosecurity communities should categorize agents based on how they impact their hosts to augment current list-based paradigms. Specifically, we propose integrating the results of multi-omics studies to identify bioagent-agnostic signatures (BASs) of disease—namely, patterns of biomarkers that accurately and reproducibly predict the impacts of infection or intoxication without prior knowledge of the causative agent. Here, we highlight three pathways that investigators might exploit as sources of signals to construct BASs and their applicability to this framework. The research community will need to forge robust interdisciplinary teams to surmount substantial experimental, technical, and data analytic challenges that stand in the way of our long-term vision. However, if successful, our functionality-based BAS model could present a means to more effectively surveil for and treat known and novel agents alike.
format	article
author	Owen P. Leiser Errett C. Hobbs Amy C. Sims George W. Korch Karen L. Taylor
author_facet	Owen P. Leiser Errett C. Hobbs Amy C. Sims George W. Korch Karen L. Taylor
author_sort	Owen P. Leiser
title	Beyond the List: Bioagent-Agnostic Signatures Could Enable a More Flexible and Resilient Biodefense Posture Than an Approach Based on Priority Agent Lists Alone
title_short	Beyond the List: Bioagent-Agnostic Signatures Could Enable a More Flexible and Resilient Biodefense Posture Than an Approach Based on Priority Agent Lists Alone
title_full	Beyond the List: Bioagent-Agnostic Signatures Could Enable a More Flexible and Resilient Biodefense Posture Than an Approach Based on Priority Agent Lists Alone
title_fullStr	Beyond the List: Bioagent-Agnostic Signatures Could Enable a More Flexible and Resilient Biodefense Posture Than an Approach Based on Priority Agent Lists Alone
title_full_unstemmed	Beyond the List: Bioagent-Agnostic Signatures Could Enable a More Flexible and Resilient Biodefense Posture Than an Approach Based on Priority Agent Lists Alone
title_sort	beyond the list: bioagent-agnostic signatures could enable a more flexible and resilient biodefense posture than an approach based on priority agent lists alone
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/194b7ddd01d94df2a72cd3a108d38336
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Beyond the List: Bioagent-Agnostic Signatures Could Enable a More Flexible and Resilient Biodefense Posture Than an Approach Based on Priority Agent Lists Alone

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