A Two-Week Insulin Infusion in Intrauterine Growth Restricted Fetal Sheep at 75% Gestation Increases Skeletal Myoblast Replication but Did Not Restore Muscle Mass or Increase Fiber Number

A Two-Week Insulin Infusion in Intrauterine Growth Restricted Fetal Sheep at 75% Gestation Increases Skeletal Myoblast Replication but Did Not Restore Muscle Mass or Increase Fiber Number

Intrauterine growth restricted (IUGR) fetuses are born with lower skeletal muscle mass, fewer proliferating myoblasts, and fewer myofibers compared to normally growing fetuses. Plasma concentrations of insulin, a myogenic growth factor, are lower in IUGR fetuses. We hypothesized that a two-week insu...

Full description

Saved in:
Bibliographic Details
Main Authors: Eileen I. Chang, Byron Hetrick, Stephanie R. Wesolowski, Carrie E. McCurdy, Paul J. Rozance, Laura D. Brown
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
IUGR fetus
skeletal muscle
insulin
myoblast
myogenesis
sheep
Diseases of the endocrine glands. Clinical endocrinology
RC648-665
Online Access:https://doaj.org/article/19521035d3f24affba43750c2b55aeb7
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/19521035d3f24affba43750c2b55aeb7

Similar Items