Structure and functional implications of WYL domain-containing bacterial DNA damage response regulator PafBC

The transcriptional activator PafBC is a regulator of mycobacterial DNA damage response and upregulates genes involved in DNA repair. Here, the authors present the crystal structure of Arthrobacter aurescens PafBC and suggest that PafBC might be activated by binding of a nucleic acid ligand, and bio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andreas U. Müller, Marc Leibundgut, Nenad Ban, Eilika Weber-Ban
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/196f288ac0fa4087a69e6983316b3dcd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:196f288ac0fa4087a69e6983316b3dcd
record_format	dspace
spelling	oai:doaj.org-article:196f288ac0fa4087a69e6983316b3dcd2021-12-02T16:57:08ZStructure and functional implications of WYL domain-containing bacterial DNA damage response regulator PafBC10.1038/s41467-019-12567-x2041-1723https://doaj.org/article/196f288ac0fa4087a69e6983316b3dcd2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12567-xhttps://doaj.org/toc/2041-1723The transcriptional activator PafBC is a regulator of mycobacterial DNA damage response and upregulates genes involved in DNA repair. Here, the authors present the crystal structure of Arthrobacter aurescens PafBC and suggest that PafBC might be activated by binding of a nucleic acid ligand, and bioinformatics analysis shows that its central WYL domain is a widespread feature in bacterial transcription factors.Andreas U. MüllerMarc LeibundgutNenad BanEilika Weber-BanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andreas U. Müller Marc Leibundgut Nenad Ban Eilika Weber-Ban Structure and functional implications of WYL domain-containing bacterial DNA damage response regulator PafBC
description	The transcriptional activator PafBC is a regulator of mycobacterial DNA damage response and upregulates genes involved in DNA repair. Here, the authors present the crystal structure of Arthrobacter aurescens PafBC and suggest that PafBC might be activated by binding of a nucleic acid ligand, and bioinformatics analysis shows that its central WYL domain is a widespread feature in bacterial transcription factors.
format	article
author	Andreas U. Müller Marc Leibundgut Nenad Ban Eilika Weber-Ban
author_facet	Andreas U. Müller Marc Leibundgut Nenad Ban Eilika Weber-Ban
author_sort	Andreas U. Müller
title	Structure and functional implications of WYL domain-containing bacterial DNA damage response regulator PafBC
title_short	Structure and functional implications of WYL domain-containing bacterial DNA damage response regulator PafBC
title_full	Structure and functional implications of WYL domain-containing bacterial DNA damage response regulator PafBC
title_fullStr	Structure and functional implications of WYL domain-containing bacterial DNA damage response regulator PafBC
title_full_unstemmed	Structure and functional implications of WYL domain-containing bacterial DNA damage response regulator PafBC
title_sort	structure and functional implications of wyl domain-containing bacterial dna damage response regulator pafbc
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/196f288ac0fa4087a69e6983316b3dcd
work_keys_str_mv	AT andreasumuller structureandfunctionalimplicationsofwyldomaincontainingbacterialdnadamageresponseregulatorpafbc AT marcleibundgut structureandfunctionalimplicationsofwyldomaincontainingbacterialdnadamageresponseregulatorpafbc AT nenadban structureandfunctionalimplicationsofwyldomaincontainingbacterialdnadamageresponseregulatorpafbc AT eilikaweberban structureandfunctionalimplicationsofwyldomaincontainingbacterialdnadamageresponseregulatorpafbc
_version_	1718382609091788800

Structure and functional implications of WYL domain-containing bacterial DNA damage response regulator PafBC

Ejemplares similares