Sinomenine Relieves Airway Remodeling By Inhibiting Epithelial-Mesenchymal Transition Through Downregulating TGF-β1 and Smad3 Expression In Vitro and In Vivo

Airway remodeling is associated with dysregulation of epithelial-mesenchymal transition (EMT) in patients with asthma. Sinomenine (Sin) is an effective, biologically active alkaloid that has been reported to suppress airway remodeling in mice with asthma. However, the molecular mechanisms behind thi...

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Auteurs principaux: Hongjuan He, Lihua Cao, Zheng Wang, Zhenzhen Wang, Jinxin Miao, Xiu-Min Li, Mingsan Miao
Format: article
Langue:EN
Publié: Frontiers Media S.A. 2021
Sujets:
EMT
Accès en ligne:https://doaj.org/article/19734fcc5b0d4066865ff70cdc7e9b5a
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