Inhibition of indole production increases the activity of quinolone antibiotics against E. coli persisters

Abstract Persisters are a sub-population of genetically sensitive bacteria that survive antibiotic treatment by entering a dormant state. The emergence of persisters from dormancy after antibiotic withdrawal leads to recurrent infection. Indole is an aromatic molecule with diverse signalling roles,...

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Autores principales: Ashraf Zarkan, Marta Matuszewska, Stephen B. Trigg, Meng Zhang, Daaniyah Belgami, Cameron Croft, Junyan Liu, Sawssen El-Ouisi, Jack Greenhalgh, James S. Duboff, Taufiq Rahman, David K. Summers
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/199fed1a3da64621a877189cfbb04dfd
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