Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals

Embryonic development produces different cell types in response to a small number of inductive signals. Here, the authors characterise how maternal factors modify chromatin to specify initial competence in Xenopus tropicalis, finding that the pioneering activity of the pluripotency factors Pou5f3 an...

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Autores principales:	George E. Gentsch, Thomas Spruce, Nick D. L. Owens, James C. Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/19a7d45a59f441d6bd501e207aa0ea14
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spelling	oai:doaj.org-article:19a7d45a59f441d6bd501e207aa0ea142021-12-02T15:36:05ZMaternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals10.1038/s41467-019-12263-w2041-1723https://doaj.org/article/19a7d45a59f441d6bd501e207aa0ea142019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12263-whttps://doaj.org/toc/2041-1723Embryonic development produces different cell types in response to a small number of inductive signals. Here, the authors characterise how maternal factors modify chromatin to specify initial competence in Xenopus tropicalis, finding that the pioneering activity of the pluripotency factors Pou5f3 and Sox3 establishes competence for germ layer formation by remodelling chromatin before the onset of signalling.George E. GentschThomas SpruceNick D. L. OwensJames C. SmithNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-22 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q George E. Gentsch Thomas Spruce Nick D. L. Owens James C. Smith Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals
description	Embryonic development produces different cell types in response to a small number of inductive signals. Here, the authors characterise how maternal factors modify chromatin to specify initial competence in Xenopus tropicalis, finding that the pioneering activity of the pluripotency factors Pou5f3 and Sox3 establishes competence for germ layer formation by remodelling chromatin before the onset of signalling.
format	article
author	George E. Gentsch Thomas Spruce Nick D. L. Owens James C. Smith
author_facet	George E. Gentsch Thomas Spruce Nick D. L. Owens James C. Smith
author_sort	George E. Gentsch
title	Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals
title_short	Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals
title_full	Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals
title_fullStr	Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals
title_full_unstemmed	Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals
title_sort	maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/19a7d45a59f441d6bd501e207aa0ea14
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Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals

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