A screen identifies the oncogenic micro-RNA miR-378a-5p as a negative regulator of oncogene-induced senescence.

Oncogene-induced senescence (OIS) can occur in response to hyperactive oncogenic signals and is believed to be a fail-safe mechanism protecting against tumorigenesis. To identify new factors involved in OIS, we performed a screen for microRNAs that can overcome or inhibit OIS in human diploid fibrob...

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Autores principales: Susanne Marije Kooistra, Lise Christine Rudkjær Nørgaard, Michael James Lees, Cornelia Steinhauer, Jens Vilstrup Johansen, Kristian Helin
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/19b38e126b7646daadcd6a9127e78f5d
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