PARP1 PARylates and stabilizes STAT5 in FLT3-ITD acute myeloid leukemia and other STAT5-activated cancers
Signal transducer and activator of transcription 5 (STAT5) signaling plays a pathogenic role in both hematologic malignancies and solid tumors. In acute myeloid leukemia (AML), internal tandem duplications of fms-like tyrosine kinase 3 (FLT3-ITD) constitutively activate the FLT3 receptor, producing...
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Autores principales: | , , , , , , |
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Formato: | article |
Lenguaje: | EN |
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Elsevier
2022
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Materias: | |
Acceso en línea: | https://doaj.org/article/1a37956d049b40a797eb0d03b6d03d1b |
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