PARP1 PARylates and stabilizes STAT5 in FLT3-ITD acute myeloid leukemia and other STAT5-activated cancers

Signal transducer and activator of transcription 5 (STAT5) signaling plays a pathogenic role in both hematologic malignancies and solid tumors. In acute myeloid leukemia (AML), internal tandem duplications of fms-like tyrosine kinase 3 (FLT3-ITD) constitutively activate the FLT3 receptor, producing...

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Autores principales: Anna J. Dellomo, Rachel Abbotts, Christian L. Eberly, Mariusz Karbowski, Maria R. Baer, Tami J. Kingsbury, Feyruz V. Rassool
Formato: article
Lenguaje:EN
Publicado: Elsevier 2022
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Acceso en línea:https://doaj.org/article/1a37956d049b40a797eb0d03b6d03d1b
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