Mechanism of FGF receptor dimerization and activation

Mechanism of FGF receptor dimerization and activation

Different fibroblast growth factor (fgf) ligands elicit specific biological responses, but the mechanism directing this specificity is unknown. Here the authors show that fgf1 and fgf2 impose specific reorganizations on the fgf receptor dimer trans-membrane helices that result in distinct level of r...

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Autores principales: Sarvenaz Sarabipour, Kalina Hristova
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/1a38664e03e44270bc0b16309c7d2525
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spelling oai:doaj.org-article:1a38664e03e44270bc0b16309c7d25252021-12-02T14:39:11ZMechanism of FGF receptor dimerization and activation10.1038/ncomms102622041-1723https://doaj.org/article/1a38664e03e44270bc0b16309c7d25252016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10262https://doaj.org/toc/2041-1723Different fibroblast growth factor (fgf) ligands elicit specific biological responses, but the mechanism directing this specificity is unknown. Here the authors show that fgf1 and fgf2 impose specific reorganizations on the fgf receptor dimer trans-membrane helices that result in distinct level of receptor activation.Sarvenaz SarabipourKalina HristovaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sarvenaz Sarabipour
Kalina Hristova
Mechanism of FGF receptor dimerization and activation
description Different fibroblast growth factor (fgf) ligands elicit specific biological responses, but the mechanism directing this specificity is unknown. Here the authors show that fgf1 and fgf2 impose specific reorganizations on the fgf receptor dimer trans-membrane helices that result in distinct level of receptor activation.
format article
author Sarvenaz Sarabipour
Kalina Hristova
author_facet Sarvenaz Sarabipour
Kalina Hristova
author_sort Sarvenaz Sarabipour
title Mechanism of FGF receptor dimerization and activation
title_short Mechanism of FGF receptor dimerization and activation
title_full Mechanism of FGF receptor dimerization and activation
title_fullStr Mechanism of FGF receptor dimerization and activation
title_full_unstemmed Mechanism of FGF receptor dimerization and activation
title_sort mechanism of fgf receptor dimerization and activation
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/1a38664e03e44270bc0b16309c7d2525
work_keys_str_mv AT sarvenazsarabipour mechanismoffgfreceptordimerizationandactivation
AT kalinahristova mechanismoffgfreceptordimerizationandactivation
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