Apc mutation enhances PyMT-induced mammary tumorigenesis.
The Adenomatous Polyposis Coli (APC) tumor suppressor gene is silenced by hypermethylation or mutated in up to 70% of human breast cancers. In mouse models, Apc mutation disrupts normal mammary development and predisposes to mammary tumor formation; however, the cooperation between APC and other mut...
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Auteurs principaux: | , , , |
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Format: | article |
Langue: | EN |
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Public Library of Science (PLoS)
2011
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Accès en ligne: | https://doaj.org/article/1a508e31c7274de4b7bff2af4c2a70e5 |
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