Apc mutation enhances PyMT-induced mammary tumorigenesis.

The Adenomatous Polyposis Coli (APC) tumor suppressor gene is silenced by hypermethylation or mutated in up to 70% of human breast cancers. In mouse models, Apc mutation disrupts normal mammary development and predisposes to mammary tumor formation; however, the cooperation between APC and other mut...

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Auteurs principaux: Jenifer R Prosperi, Andrey I Khramtsov, Galina F Khramtsova, Kathleen H Goss
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2011
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Accès en ligne:https://doaj.org/article/1a508e31c7274de4b7bff2af4c2a70e5
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