Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis.

Stochastic fluctuations in gene expression give rise to cell-to-cell variability in protein levels which can potentially cause variability in cellular phenotype. For TRAIL (TNF-related apoptosis-inducing ligand) variability manifests itself as dramatic differences in the time between ligand exposure...

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Auteurs principaux: Suzanne Gaudet, Sabrina L Spencer, William W Chen, Peter K Sorger
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2012
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Accès en ligne:https://doaj.org/article/1a70568a02dd49bdba33d80b7ca035f9
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