Exon first nucleotide mutations in splicing: evaluation of in silico prediction tools.

Mutations in the first nucleotide of exons (E(+1)) mostly affect pre-mRNA splicing when found in AG-dependent 3' splice sites, whereas AG-independent splice sites are more resistant. The AG-dependency, however, may be difficult to assess just from primary sequence data as it depends on the qual...

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Bibliographic Details
Main Authors: Lucie Grodecká, Pavla Lockerová, Barbora Ravčuková, Emanuele Buratti, Francisco E Baralle, Ladislav Dušek, Tomáš Freiberger
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
R
Q
Online Access:https://doaj.org/article/1a828e23d9c641e8b2d7b6964207b25e
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