Both Terminal Oxidases Contribute to Fitness and Virulence during Organ-Specific <named-content content-type="genus-species">Staphylococcus aureus</named-content> Colonization

ABSTRACT In their recent article, Hammer et al. (N. D. Hammer, M. L. Reniere, J. E. Cassat, Y. Zhang, A. O. Hirsch, M. Indriati Hood, and E. P. Skaar, mBio 4:e00241-13, 2013) described the dual functions of the two terminal oxidases encoded by cydBA and qoxABCD in Staphylococcus aureus. The aerobic...

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Main Authors:	Friedrich Götz, Sonja Mayer
Format:	article
Language:	EN
Published:	American Society for Microbiology 2013
Subjects:	Microbiology QR1-502
Online Access:	https://doaj.org/article/1a8ac4a5ad784cdea24071f00b0cc1a8
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spelling	oai:doaj.org-article:1a8ac4a5ad784cdea24071f00b0cc1a82021-11-15T15:42:32ZBoth Terminal Oxidases Contribute to Fitness and Virulence during Organ-Specific <named-content content-type="genus-species">Staphylococcus aureus</named-content> Colonization10.1128/mBio.00976-132150-7511https://doaj.org/article/1a8ac4a5ad784cdea24071f00b0cc1a82013-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00976-13https://doaj.org/toc/2150-7511ABSTRACT In their recent article, Hammer et al. (N. D. Hammer, M. L. Reniere, J. E. Cassat, Y. Zhang, A. O. Hirsch, M. Indriati Hood, and E. P. Skaar, mBio 4:e00241-13, 2013) described the dual functions of the two terminal oxidases encoded by cydBA and qoxABCD in Staphylococcus aureus. The aerobic growth of cydB or qoxB single mutant bacteria was barely affected. However, a cydB qoxB double mutant was completely unable to respire and exhibited the small-colony variant phenotype that is typical of menaquinone and heme biosynthesis mutants. The authors found that the two terminal oxidases play a role in pathogenesis. In a systemic mouse infection model, it turned out that in the cydB mutant the bacterial burden was significantly decreased in the heart, kidneys, and liver, while in the qoxB mutant it was decreased only in the liver. These results illustrate that both terminal oxidases contribute to fitness and virulence, representing promising candidates for the development of antimicrobials.Friedrich GötzSonja MayerAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 6 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Friedrich Götz Sonja Mayer Both Terminal Oxidases Contribute to Fitness and Virulence during Organ-Specific <named-content content-type="genus-species">Staphylococcus aureus</named-content> Colonization
description	ABSTRACT In their recent article, Hammer et al. (N. D. Hammer, M. L. Reniere, J. E. Cassat, Y. Zhang, A. O. Hirsch, M. Indriati Hood, and E. P. Skaar, mBio 4:e00241-13, 2013) described the dual functions of the two terminal oxidases encoded by cydBA and qoxABCD in Staphylococcus aureus. The aerobic growth of cydB or qoxB single mutant bacteria was barely affected. However, a cydB qoxB double mutant was completely unable to respire and exhibited the small-colony variant phenotype that is typical of menaquinone and heme biosynthesis mutants. The authors found that the two terminal oxidases play a role in pathogenesis. In a systemic mouse infection model, it turned out that in the cydB mutant the bacterial burden was significantly decreased in the heart, kidneys, and liver, while in the qoxB mutant it was decreased only in the liver. These results illustrate that both terminal oxidases contribute to fitness and virulence, representing promising candidates for the development of antimicrobials.
format	article
author	Friedrich Götz Sonja Mayer
author_facet	Friedrich Götz Sonja Mayer
author_sort	Friedrich Götz
title	Both Terminal Oxidases Contribute to Fitness and Virulence during Organ-Specific <named-content content-type="genus-species">Staphylococcus aureus</named-content> Colonization
title_short	Both Terminal Oxidases Contribute to Fitness and Virulence during Organ-Specific <named-content content-type="genus-species">Staphylococcus aureus</named-content> Colonization
title_full	Both Terminal Oxidases Contribute to Fitness and Virulence during Organ-Specific <named-content content-type="genus-species">Staphylococcus aureus</named-content> Colonization
title_fullStr	Both Terminal Oxidases Contribute to Fitness and Virulence during Organ-Specific <named-content content-type="genus-species">Staphylococcus aureus</named-content> Colonization
title_full_unstemmed	Both Terminal Oxidases Contribute to Fitness and Virulence during Organ-Specific <named-content content-type="genus-species">Staphylococcus aureus</named-content> Colonization
title_sort	both terminal oxidases contribute to fitness and virulence during organ-specific <named-content content-type="genus-species">staphylococcus aureus</named-content> colonization
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/1a8ac4a5ad784cdea24071f00b0cc1a8
work_keys_str_mv	AT friedrichgotz bothterminaloxidasescontributetofitnessandvirulenceduringorganspecificnamedcontentcontenttypegenusspeciesstaphylococcusaureusnamedcontentcolonization AT sonjamayer bothterminaloxidasescontributetofitnessandvirulenceduringorganspecificnamedcontentcontenttypegenusspeciesstaphylococcusaureusnamedcontentcolonization
_version_	1718427569204756480

Both Terminal Oxidases Contribute to Fitness and Virulence during Organ-Specific <named-content content-type="genus-species">Staphylococcus aureus</named-content> Colonization

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