DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells

Caspase independent alternative cell death (ACD) pathways exist, but have been largely investigated under non-physiological conditions. Here, the authors show that Drosophila primordial germ cells normally elicit DNase II-dependent DNA damage, triggering a parthanatos-like ACD pathway.

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Bibliographic Details
Main Authors: Lama Tarayrah-Ibraheim, Elital Chass Maurice, Guy Hadary, Sharon Ben-Hur, Alina Kolpakova, Tslil Braun, Yoav Peleg, Keren Yacobi-Sharon, Eli Arama
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/1a9965c07ebe4575a42eb34b43c4877a
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