Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells

Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells

Abstract Ouabain (OUA) is a cardiac glycoside that binds to Na+,K+-ATPase (NKA), a conserved membrane protein that controls cell transmembrane ionic concentrations and requires ATP hydrolysis. At nM concentrations, OUA activates signaling pathways that are not related to its typical inhibitory effec...

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Autores principales: Paula F. Kinoshita, Lidia M. Yshii, Ana Maria M. Orellana, Amanda G. Paixão, Andrea R. Vasconcelos, Larissa de Sá Lima, Elisa M. Kawamoto, Cristoforo Scavone
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/1adf6f5253cc4c8bb05fb066494c48ed
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