MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. Here the authors show that MLKL trafficking and plasma membrane accumulation are crucial necroptosis checkpoints, and that accumulation of phosphorylated MLKL at intercellular junc...

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Autores principales:	Andre L. Samson, Ying Zhang, Niall D. Geoghegan, Xavier J. Gavin, Katherine A. Davies, Michael J. Mlodzianoski, Lachlan W. Whitehead, Daniel Frank, Sarah E. Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N. Young, Annette V. Jacobsen, Wayne Cawthorne, Emma J. Petrie, Maree C. Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M. Hildebrand, John Silke, Kelly L. Rogers, Guillaume Lessene, Edwin D. Hawkins, James M. Murphy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ae829760f7e467a8e81c5fd0160cbfe
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spelling	oai:doaj.org-article:1ae829760f7e467a8e81c5fd0160cbfe2021-12-02T16:04:25ZMLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis10.1038/s41467-020-16887-12041-1723https://doaj.org/article/1ae829760f7e467a8e81c5fd0160cbfe2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16887-1https://doaj.org/toc/2041-1723Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. Here the authors show that MLKL trafficking and plasma membrane accumulation are crucial necroptosis checkpoints, and that accumulation of phosphorylated MLKL at intercellular junctions promotes necroptosis.Andre L. SamsonYing ZhangNiall D. GeogheganXavier J. GavinKatherine A. DaviesMichael J. MlodzianoskiLachlan W. WhiteheadDaniel FrankSarah E. GarnishCheree FitzgibbonAnne HempelSamuel N. YoungAnnette V. JacobsenWayne CawthorneEmma J. PetrieMaree C. FauxKristy Shield-ArtinNajoua LalaouiJoanne M. HildebrandJohn SilkeKelly L. RogersGuillaume LesseneEdwin D. HawkinsJames M. MurphyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andre L. Samson Ying Zhang Niall D. Geoghegan Xavier J. Gavin Katherine A. Davies Michael J. Mlodzianoski Lachlan W. Whitehead Daniel Frank Sarah E. Garnish Cheree Fitzgibbon Anne Hempel Samuel N. Young Annette V. Jacobsen Wayne Cawthorne Emma J. Petrie Maree C. Faux Kristy Shield-Artin Najoua Lalaoui Joanne M. Hildebrand John Silke Kelly L. Rogers Guillaume Lessene Edwin D. Hawkins James M. Murphy MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
description	Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. Here the authors show that MLKL trafficking and plasma membrane accumulation are crucial necroptosis checkpoints, and that accumulation of phosphorylated MLKL at intercellular junctions promotes necroptosis.
format	article
author	Andre L. Samson Ying Zhang Niall D. Geoghegan Xavier J. Gavin Katherine A. Davies Michael J. Mlodzianoski Lachlan W. Whitehead Daniel Frank Sarah E. Garnish Cheree Fitzgibbon Anne Hempel Samuel N. Young Annette V. Jacobsen Wayne Cawthorne Emma J. Petrie Maree C. Faux Kristy Shield-Artin Najoua Lalaoui Joanne M. Hildebrand John Silke Kelly L. Rogers Guillaume Lessene Edwin D. Hawkins James M. Murphy
author_facet	Andre L. Samson Ying Zhang Niall D. Geoghegan Xavier J. Gavin Katherine A. Davies Michael J. Mlodzianoski Lachlan W. Whitehead Daniel Frank Sarah E. Garnish Cheree Fitzgibbon Anne Hempel Samuel N. Young Annette V. Jacobsen Wayne Cawthorne Emma J. Petrie Maree C. Faux Kristy Shield-Artin Najoua Lalaoui Joanne M. Hildebrand John Silke Kelly L. Rogers Guillaume Lessene Edwin D. Hawkins James M. Murphy
author_sort	Andre L. Samson
title	MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
title_short	MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
title_full	MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
title_fullStr	MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
title_full_unstemmed	MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
title_sort	mlkl trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1ae829760f7e467a8e81c5fd0160cbfe
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MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

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