Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma

Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma

Characterising the clonal architecture of Adult T-cell leukemia-lymphoma (ATL) remains crucial. Here, the authors develop a capture-based sequencing panel and use deep DNA and single cell RNA sequencing and report distinct genomic and transcriptomic features associated with subclonal evolution.

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Auteurs principaux: Makoto Yamagishi, Miyuki Kubokawa, Yuta Kuze, Ayako Suzuki, Akari Yokomizo, Seiichiro Kobayashi, Makoto Nakashima, Junya Makiyama, Masako Iwanaga, Takahiro Fukuda, Toshiki Watanabe, Yutaka Suzuki, Kaoru Uchimaru
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Science
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Accès en ligne:https://doaj.org/article/1ae9c9d8ca5d499bb14d06d1195e38c0
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Internet

https://doaj.org/article/1ae9c9d8ca5d499bb14d06d1195e38c0

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