Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma
Characterising the clonal architecture of Adult T-cell leukemia-lymphoma (ATL) remains crucial. Here, the authors develop a capture-based sequencing panel and use deep DNA and single cell RNA sequencing and report distinct genomic and transcriptomic features associated with subclonal evolution.
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Nature Portfolio
2021
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oai:doaj.org-article:1ae9c9d8ca5d499bb14d06d1195e38c02021-12-02T15:08:12ZChronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma10.1038/s41467-021-25101-92041-1723https://doaj.org/article/1ae9c9d8ca5d499bb14d06d1195e38c02021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25101-9https://doaj.org/toc/2041-1723Characterising the clonal architecture of Adult T-cell leukemia-lymphoma (ATL) remains crucial. Here, the authors develop a capture-based sequencing panel and use deep DNA and single cell RNA sequencing and report distinct genomic and transcriptomic features associated with subclonal evolution.Makoto YamagishiMiyuki KubokawaYuta KuzeAyako SuzukiAkari YokomizoSeiichiro KobayashiMakoto NakashimaJunya MakiyamaMasako IwanagaTakahiro FukudaToshiki WatanabeYutaka SuzukiKaoru UchimaruNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Makoto Yamagishi Miyuki Kubokawa Yuta Kuze Ayako Suzuki Akari Yokomizo Seiichiro Kobayashi Makoto Nakashima Junya Makiyama Masako Iwanaga Takahiro Fukuda Toshiki Watanabe Yutaka Suzuki Kaoru Uchimaru Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma |
| description |
Characterising the clonal architecture of Adult T-cell leukemia-lymphoma (ATL) remains crucial. Here, the authors develop a capture-based sequencing panel and use deep DNA and single cell RNA sequencing and report distinct genomic and transcriptomic features associated with subclonal evolution. |
| format |
article |
| author |
Makoto Yamagishi Miyuki Kubokawa Yuta Kuze Ayako Suzuki Akari Yokomizo Seiichiro Kobayashi Makoto Nakashima Junya Makiyama Masako Iwanaga Takahiro Fukuda Toshiki Watanabe Yutaka Suzuki Kaoru Uchimaru |
| author_facet |
Makoto Yamagishi Miyuki Kubokawa Yuta Kuze Ayako Suzuki Akari Yokomizo Seiichiro Kobayashi Makoto Nakashima Junya Makiyama Masako Iwanaga Takahiro Fukuda Toshiki Watanabe Yutaka Suzuki Kaoru Uchimaru |
| author_sort |
Makoto Yamagishi |
| title |
Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma |
| title_short |
Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma |
| title_full |
Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma |
| title_fullStr |
Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma |
| title_full_unstemmed |
Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma |
| title_sort |
chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult t cell leukemia-lymphoma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1ae9c9d8ca5d499bb14d06d1195e38c0 |
| work_keys_str_mv |
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| _version_ |
1718388236381847552 |