Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma

Characterising the clonal architecture of Adult T-cell leukemia-lymphoma (ATL) remains crucial. Here, the authors develop a capture-based sequencing panel and use deep DNA and single cell RNA sequencing and report distinct genomic and transcriptomic features associated with subclonal evolution.

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Detalles Bibliográficos
Autores principales:	Makoto Yamagishi, Miyuki Kubokawa, Yuta Kuze, Ayako Suzuki, Akari Yokomizo, Seiichiro Kobayashi, Makoto Nakashima, Junya Makiyama, Masako Iwanaga, Takahiro Fukuda, Toshiki Watanabe, Yutaka Suzuki, Kaoru Uchimaru
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ae9c9d8ca5d499bb14d06d1195e38c0
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Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma

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