Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.
The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity. The transcription factor T-bet (TBX21) specifies the Th1 lineage and represses alternative T cell fates. Genome-wide...
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| Autores principales: | , , , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2017
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/1b047c1f9aaf46738e2b7b4684f706e9 |
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