Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.

The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity. The transcription factor T-bet (TBX21) specifies the Th1 lineage and represses alternative T cell fates. Genome-wide...

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Detalles Bibliográficos
Autores principales: Katrina Soderquest, Arnulf Hertweck, Claudia Giambartolomei, Stephen Henderson, Rami Mohamed, Rimma Goldberg, Esperanza Perucha, Lude Franke, Javier Herrero, Vincent Plagnol, Richard G Jenner, Graham M Lord
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2017
Materias:
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/1b047c1f9aaf46738e2b7b4684f706e9
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