Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis

Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis

Abstract V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4+ and CD8+ T cell activation when expressed on antigen-presenting cells. Vsir −/− mice developed loss of peripheral tolerance and multi-organ chronic inflammatory p...

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Autores principales: Na Li, Wenwen Xu, Ying Yuan, Natarajan Ayithan, Yasutomo Imai, Xuesong Wu, Halli Miller, Michael Olson, Yunfeng Feng, Yina H. Huang, Mary Jo Turk, Samuel T. Hwang, Subramaniam Malarkannan, Li Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/1b0571cb47a145ed901429ee57439f62
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https://doaj.org/article/1b0571cb47a145ed901429ee57439f62

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