Signaling through the S1P−S1PR Axis in the Gut, the Immune and the Central Nervous System in Multiple Sclerosis: Implication for Pathogenesis and Treatment

Signaling through the S1P−S1PR Axis in the Gut, the Immune and the Central Nervous System in Multiple Sclerosis: Implication for Pathogenesis and Treatment

Sphingosine 1-phosphate (S1P) is a signaling molecule with complex biological functions that are exerted through the activation of sphingosine 1-phosphate receptors 1–5 (S1PR1–5). S1PR expression is necessary for cell proliferation, angiogenesis, neurogenesis and, importantly, for the egress of lymp...

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Autores principales: Simela Chatzikonstantinou, Vasiliki Poulidou, Marianthi Arnaoutoglou, Dimitrios Kazis, Ioannis Heliopoulos, Nikolaos Grigoriadis, Marina Boziki
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
sphingosine 1-phoshate
sphingosine 1-phosphate receptors
multiple sclerosis
gut–brain axis
gut microbiota
fingolimod
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/1b0c7d85cb8f43609f39a7f1b9a5c267
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https://doaj.org/article/1b0c7d85cb8f43609f39a7f1b9a5c267

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