MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia

MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia

The alternative splicing regulator MBNL1 is overexpressed in MLL-rearranged leukaemia. Here, the authors show that MBNL1-mediated alternative splicing leads to a specific splicing profile in MLL-rearranged leukaemia and loss or inhibition of MBNL1 impairs leukaemia development in vitro and in vivo.

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Bibliographic Details
Main Authors: Svetlana S. Itskovich, Arun Gurunathan, Jason Clark, Matthew Burwinkel, Mark Wunderlich, Mikaela R. Berger, Aishwarya Kulkarni, Kashish Chetal, Meenakshi Venkatasubramanian, Nathan Salomonis, Ashish R. Kumar, Lynn H. Lee
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
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Online Access:https://doaj.org/article/1b153388c9a248a7aa9ef84624fc49dd
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https://doaj.org/article/1b153388c9a248a7aa9ef84624fc49dd

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