MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia

The alternative splicing regulator MBNL1 is overexpressed in MLL-rearranged leukaemia. Here, the authors show that MBNL1-mediated alternative splicing leads to a specific splicing profile in MLL-rearranged leukaemia and loss or inhibition of MBNL1 impairs leukaemia development in vitro and in vivo.

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Autores principales:	Svetlana S. Itskovich, Arun Gurunathan, Jason Clark, Matthew Burwinkel, Mark Wunderlich, Mikaela R. Berger, Aishwarya Kulkarni, Kashish Chetal, Meenakshi Venkatasubramanian, Nathan Salomonis, Ashish R. Kumar, Lynn H. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1b153388c9a248a7aa9ef84624fc49dd
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spelling	oai:doaj.org-article:1b153388c9a248a7aa9ef84624fc49dd2021-12-02T15:42:58ZMBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia10.1038/s41467-020-15733-82041-1723https://doaj.org/article/1b153388c9a248a7aa9ef84624fc49dd2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15733-8https://doaj.org/toc/2041-1723The alternative splicing regulator MBNL1 is overexpressed in MLL-rearranged leukaemia. Here, the authors show that MBNL1-mediated alternative splicing leads to a specific splicing profile in MLL-rearranged leukaemia and loss or inhibition of MBNL1 impairs leukaemia development in vitro and in vivo.Svetlana S. ItskovichArun GurunathanJason ClarkMatthew BurwinkelMark WunderlichMikaela R. BergerAishwarya KulkarniKashish ChetalMeenakshi VenkatasubramanianNathan SalomonisAshish R. KumarLynn H. LeeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Svetlana S. Itskovich Arun Gurunathan Jason Clark Matthew Burwinkel Mark Wunderlich Mikaela R. Berger Aishwarya Kulkarni Kashish Chetal Meenakshi Venkatasubramanian Nathan Salomonis Ashish R. Kumar Lynn H. Lee MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
description	The alternative splicing regulator MBNL1 is overexpressed in MLL-rearranged leukaemia. Here, the authors show that MBNL1-mediated alternative splicing leads to a specific splicing profile in MLL-rearranged leukaemia and loss or inhibition of MBNL1 impairs leukaemia development in vitro and in vivo.
format	article
author	Svetlana S. Itskovich Arun Gurunathan Jason Clark Matthew Burwinkel Mark Wunderlich Mikaela R. Berger Aishwarya Kulkarni Kashish Chetal Meenakshi Venkatasubramanian Nathan Salomonis Ashish R. Kumar Lynn H. Lee
author_facet	Svetlana S. Itskovich Arun Gurunathan Jason Clark Matthew Burwinkel Mark Wunderlich Mikaela R. Berger Aishwarya Kulkarni Kashish Chetal Meenakshi Venkatasubramanian Nathan Salomonis Ashish R. Kumar Lynn H. Lee
author_sort	Svetlana S. Itskovich
title	MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
title_short	MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
title_full	MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
title_fullStr	MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
title_full_unstemmed	MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
title_sort	mbnl1 regulates essential alternative rna splicing patterns in mll-rearranged leukemia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1b153388c9a248a7aa9ef84624fc49dd
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MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia

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