Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans

Recent evidence has questioned the dogma of strict maternal transmission of mitochondrial DNA (mtDNA) in humans. Wei et al. saw no evidence of paternal transmission of mtDNA in 11,035 human trios, and show that nuclear-mitochondrial segments (NUMTs) can give the impression of paternal mtDNA transmis...

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Autores principales:	Wei Wei, Alistair T. Pagnamenta, Nicholas Gleadall, Alba Sanchis-Juan, Jonathan Stephens, John Broxholme, Salih Tuna, Christopher A. Odhams, Genomics England Research Consortium, NIHR BioResource, Carl Fratter, Ernest Turro, Mark J. Caulfield, Jenny C. Taylor, Shamima Rahman, Patrick F. Chinnery
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1b33ee54b03a414c950db059cdfe623d
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spelling	oai:doaj.org-article:1b33ee54b03a414c950db059cdfe623d2021-12-02T14:40:38ZNuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans10.1038/s41467-020-15336-32041-1723https://doaj.org/article/1b33ee54b03a414c950db059cdfe623d2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15336-3https://doaj.org/toc/2041-1723Recent evidence has questioned the dogma of strict maternal transmission of mitochondrial DNA (mtDNA) in humans. Wei et al. saw no evidence of paternal transmission of mtDNA in 11,035 human trios, and show that nuclear-mitochondrial segments (NUMTs) can give the impression of paternal mtDNA transmission, but are actually inherited through the nuclear genome.Wei WeiAlistair T. PagnamentaNicholas GleadallAlba Sanchis-JuanJonathan StephensJohn BroxholmeSalih TunaChristopher A. OdhamsGenomics England Research ConsortiumNIHR BioResourceCarl FratterErnest TurroMark J. CaulfieldJenny C. TaylorShamima RahmanPatrick F. ChinneryNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Wei Alistair T. Pagnamenta Nicholas Gleadall Alba Sanchis-Juan Jonathan Stephens John Broxholme Salih Tuna Christopher A. Odhams Genomics England Research Consortium NIHR BioResource Carl Fratter Ernest Turro Mark J. Caulfield Jenny C. Taylor Shamima Rahman Patrick F. Chinnery Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans
description	Recent evidence has questioned the dogma of strict maternal transmission of mitochondrial DNA (mtDNA) in humans. Wei et al. saw no evidence of paternal transmission of mtDNA in 11,035 human trios, and show that nuclear-mitochondrial segments (NUMTs) can give the impression of paternal mtDNA transmission, but are actually inherited through the nuclear genome.
format	article
author	Wei Wei Alistair T. Pagnamenta Nicholas Gleadall Alba Sanchis-Juan Jonathan Stephens John Broxholme Salih Tuna Christopher A. Odhams Genomics England Research Consortium NIHR BioResource Carl Fratter Ernest Turro Mark J. Caulfield Jenny C. Taylor Shamima Rahman Patrick F. Chinnery
author_facet	Wei Wei Alistair T. Pagnamenta Nicholas Gleadall Alba Sanchis-Juan Jonathan Stephens John Broxholme Salih Tuna Christopher A. Odhams Genomics England Research Consortium NIHR BioResource Carl Fratter Ernest Turro Mark J. Caulfield Jenny C. Taylor Shamima Rahman Patrick F. Chinnery
author_sort	Wei Wei
title	Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans
title_short	Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans
title_full	Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans
title_fullStr	Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans
title_full_unstemmed	Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans
title_sort	nuclear-mitochondrial dna segments resemble paternally inherited mitochondrial dna in humans
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1b33ee54b03a414c950db059cdfe623d
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Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans

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