Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination
Circulating tumour cells contribute to metastatic spread. Here the authors find that beta-chain of haemoglobin is overexpressed in those cells and protects them from oxidative stress, prolonging their survival in circulation and thereby increasing the likelihood of metastasis formation.
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Nature Portfolio
2017
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oai:doaj.org-article:1b34881d11b34839baa13a42e1ec312c2021-12-02T15:38:52ZExpression of β-globin by cancer cells promotes cell survival during blood-borne dissemination10.1038/ncomms143442041-1723https://doaj.org/article/1b34881d11b34839baa13a42e1ec312c2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14344https://doaj.org/toc/2041-1723Circulating tumour cells contribute to metastatic spread. Here the authors find that beta-chain of haemoglobin is overexpressed in those cells and protects them from oxidative stress, prolonging their survival in circulation and thereby increasing the likelihood of metastasis formation.Yu ZhengDavid T. MiyamotoBen S. WittnerJames P. SullivanNicola AcetoNicole Vincent JordanMin YuNezihi Murat KarabacakValentine ComaillsRobert MorrisRushil DesaiNiyati DesaiErin EmmonsJohn D. MilnerRichard J. LeeChin-Lee WuLecia V. SequistWilhelm HaasDavid T. TingMehmet TonerSridhar RamaswamyShyamala MaheswaranDaniel A. HaberNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yu Zheng David T. Miyamoto Ben S. Wittner James P. Sullivan Nicola Aceto Nicole Vincent Jordan Min Yu Nezihi Murat Karabacak Valentine Comaills Robert Morris Rushil Desai Niyati Desai Erin Emmons John D. Milner Richard J. Lee Chin-Lee Wu Lecia V. Sequist Wilhelm Haas David T. Ting Mehmet Toner Sridhar Ramaswamy Shyamala Maheswaran Daniel A. Haber Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination |
| description |
Circulating tumour cells contribute to metastatic spread. Here the authors find that beta-chain of haemoglobin is overexpressed in those cells and protects them from oxidative stress, prolonging their survival in circulation and thereby increasing the likelihood of metastasis formation. |
| format |
article |
| author |
Yu Zheng David T. Miyamoto Ben S. Wittner James P. Sullivan Nicola Aceto Nicole Vincent Jordan Min Yu Nezihi Murat Karabacak Valentine Comaills Robert Morris Rushil Desai Niyati Desai Erin Emmons John D. Milner Richard J. Lee Chin-Lee Wu Lecia V. Sequist Wilhelm Haas David T. Ting Mehmet Toner Sridhar Ramaswamy Shyamala Maheswaran Daniel A. Haber |
| author_facet |
Yu Zheng David T. Miyamoto Ben S. Wittner James P. Sullivan Nicola Aceto Nicole Vincent Jordan Min Yu Nezihi Murat Karabacak Valentine Comaills Robert Morris Rushil Desai Niyati Desai Erin Emmons John D. Milner Richard J. Lee Chin-Lee Wu Lecia V. Sequist Wilhelm Haas David T. Ting Mehmet Toner Sridhar Ramaswamy Shyamala Maheswaran Daniel A. Haber |
| author_sort |
Yu Zheng |
| title |
Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination |
| title_short |
Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination |
| title_full |
Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination |
| title_fullStr |
Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination |
| title_full_unstemmed |
Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination |
| title_sort |
expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/1b34881d11b34839baa13a42e1ec312c |
| work_keys_str_mv |
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