Thymoquinone Potentiates the Effect of Phenytoin against Electroshock-Induced Convulsions in Rats by Reducing the Hyperactivation of m-TOR Pathway and Neuroinflammation: Evidence from In Vivo, In Vitro and Computational Studies

Thymoquinone Potentiates the Effect of Phenytoin against Electroshock-Induced Convulsions in Rats by Reducing the Hyperactivation of m-TOR Pathway and Neuroinflammation: Evidence from In Vivo, In Vitro and Computational Studies

Epilepsy is a chronic neurodegenerative disease characterized by multiple seizures, hereto 35% of patients remain poor responders. Phenytoin (PHT; 20 and 40 mg/kg) and thymoquinone (THQ; 40 and 80 mg/kg) were given alone and as a low dose combination for 14 days (p.o), prior to challenge with maxima...

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Autores principales: Faheem Hyder Pottoo, Mohammed Salahuddin, Firdos Alam Khan, Fadhel Alomar, Marwa Abdullah AL Dhamen, Abrar Fouad Alhashim, Hawra Hussain Alqattan, Mohamed S. Gomaa, Mohammad N. Alomary
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
phenytoin
thymoquinone
PI3K/Akt/m-TOR signaling
grand mal seizures
neuronal inflammation
convulsions
Medicine
R
Pharmacy and materia medica
RS1-441
Acceso en línea:https://doaj.org/article/1b8a59fae575450d8009aa7d9a72c8d3
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https://doaj.org/article/1b8a59fae575450d8009aa7d9a72c8d3

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