Intranasal delivery of plasma and platelet growth factors using PRGF-Endoret system enhances neurogenesis in a mouse model of Alzheimer's disease.

Neurodegeneration together with a reduction in neurogenesis are cardinal features of Alzheimer's disease (AD) induced by a combination of toxic amyloid-β peptide (Aβ) and a loss of trophic factor support. Amelioration of these was assessed with diverse neurotrophins in experimental therapeutic...

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Autores principales: Eduardo Anitua, Consuelo Pascual, Rocio Pérez-Gonzalez, Desiree Antequera, Sabino Padilla, Gorka Orive, Eva Carro
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/1ba31aaaa83145c68abc9f0c11fd0dfa
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