Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show that mice carrying the same mutation recapitulate the human disease, and find that treatment with anti-oxidants including cobinamide, a vitamin B12 analog, prevents...

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Bibliographic Details
Main Authors: Gerburg K. Schwaerzer, Hema Kalyanaraman, Darren E. Casteel, Nancy D. Dalton, Yusu Gu, Seunghoe Lee, Shunhui Zhuang, Nisreen Wahwah, Jan M. Schilling, Hemal H. Patel, Qian Zhang, Ayako Makino, Dianna M. Milewicz, Kirk L. Peterson, Gerry R. Boss, Renate B. Pilz
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/1bb1d770c1fc4afd9a8c4a6eaa023c6b
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https://doaj.org/article/1bb1d770c1fc4afd9a8c4a6eaa023c6b

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