Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show that mice carrying the same mutation recapitulate the human disease, and find that treatment with anti-oxidants including cobinamide, a vitamin B12 analog, prevents...

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Autores principales:	Gerburg K. Schwaerzer, Hema Kalyanaraman, Darren E. Casteel, Nancy D. Dalton, Yusu Gu, Seunghoe Lee, Shunhui Zhuang, Nisreen Wahwah, Jan M. Schilling, Hemal H. Patel, Qian Zhang, Ayako Makino, Dianna M. Milewicz, Kirk L. Peterson, Gerry R. Boss, Renate B. Pilz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1bb1d770c1fc4afd9a8c4a6eaa023c6b
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spelling	oai:doaj.org-article:1bb1d770c1fc4afd9a8c4a6eaa023c6b2021-12-02T16:58:14ZAortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog10.1038/s41467-019-11389-12041-1723https://doaj.org/article/1bb1d770c1fc4afd9a8c4a6eaa023c6b2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11389-1https://doaj.org/toc/2041-1723Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show that mice carrying the same mutation recapitulate the human disease, and find that treatment with anti-oxidants including cobinamide, a vitamin B12 analog, prevents disease progression.Gerburg K. SchwaerzerHema KalyanaramanDarren E. CasteelNancy D. DaltonYusu GuSeunghoe LeeShunhui ZhuangNisreen WahwahJan M. SchillingHemal H. PatelQian ZhangAyako MakinoDianna M. MilewiczKirk L. PetersonGerry R. BossRenate B. PilzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gerburg K. Schwaerzer Hema Kalyanaraman Darren E. Casteel Nancy D. Dalton Yusu Gu Seunghoe Lee Shunhui Zhuang Nisreen Wahwah Jan M. Schilling Hemal H. Patel Qian Zhang Ayako Makino Dianna M. Milewicz Kirk L. Peterson Gerry R. Boss Renate B. Pilz Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog
description	Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show that mice carrying the same mutation recapitulate the human disease, and find that treatment with anti-oxidants including cobinamide, a vitamin B12 analog, prevents disease progression.
format	article
author	Gerburg K. Schwaerzer Hema Kalyanaraman Darren E. Casteel Nancy D. Dalton Yusu Gu Seunghoe Lee Shunhui Zhuang Nisreen Wahwah Jan M. Schilling Hemal H. Patel Qian Zhang Ayako Makino Dianna M. Milewicz Kirk L. Peterson Gerry R. Boss Renate B. Pilz
author_facet	Gerburg K. Schwaerzer Hema Kalyanaraman Darren E. Casteel Nancy D. Dalton Yusu Gu Seunghoe Lee Shunhui Zhuang Nisreen Wahwah Jan M. Schilling Hemal H. Patel Qian Zhang Ayako Makino Dianna M. Milewicz Kirk L. Peterson Gerry R. Boss Renate B. Pilz
author_sort	Gerburg K. Schwaerzer
title	Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog
title_short	Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog
title_full	Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog
title_fullStr	Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog
title_full_unstemmed	Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog
title_sort	aortic pathology from protein kinase g activation is prevented by an antioxidant vitamin b12 analog
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1bb1d770c1fc4afd9a8c4a6eaa023c6b
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Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

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