LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function
The autophagic and Hippo pathways are both well characterized contributors to cancer. Here, Tang et al show that LATS1, but not LATS2, negatively regulates autophagy by promoting Beclin1 ubiquitination, which restricts lethal autophagy induced by sorafenib treatment in cancer cells.
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Nature Portfolio
2019
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oai:doaj.org-article:1bd4d7c4bf134f42b2b569c6511ab4d12021-12-02T16:58:18ZLATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function10.1038/s41467-019-13591-72041-1723https://doaj.org/article/1bd4d7c4bf134f42b2b569c6511ab4d12019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13591-7https://doaj.org/toc/2041-1723The autophagic and Hippo pathways are both well characterized contributors to cancer. Here, Tang et al show that LATS1, but not LATS2, negatively regulates autophagy by promoting Beclin1 ubiquitination, which restricts lethal autophagy induced by sorafenib treatment in cancer cells.Fengyuan TangRuize GaoBeena Jeevan-RajChristof B. WyssRavi K. R. KalathurSalvatore PiscuoglioCharlotte K. Y. NgSravanth K. HindupurSandro NuciforoEva DazertThomas BockShuang SongDavid BuechelMarco F. MoriniAlexander HergovichPatrick MatthiasDae-Sik LimLuigi M. TerraccianoMarkus H. HeimMichael N. HallGerhard ChristoforiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Fengyuan Tang Ruize Gao Beena Jeevan-Raj Christof B. Wyss Ravi K. R. Kalathur Salvatore Piscuoglio Charlotte K. Y. Ng Sravanth K. Hindupur Sandro Nuciforo Eva Dazert Thomas Bock Shuang Song David Buechel Marco F. Morini Alexander Hergovich Patrick Matthias Dae-Sik Lim Luigi M. Terracciano Markus H. Heim Michael N. Hall Gerhard Christofori LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function |
| description |
The autophagic and Hippo pathways are both well characterized contributors to cancer. Here, Tang et al show that LATS1, but not LATS2, negatively regulates autophagy by promoting Beclin1 ubiquitination, which restricts lethal autophagy induced by sorafenib treatment in cancer cells. |
| format |
article |
| author |
Fengyuan Tang Ruize Gao Beena Jeevan-Raj Christof B. Wyss Ravi K. R. Kalathur Salvatore Piscuoglio Charlotte K. Y. Ng Sravanth K. Hindupur Sandro Nuciforo Eva Dazert Thomas Bock Shuang Song David Buechel Marco F. Morini Alexander Hergovich Patrick Matthias Dae-Sik Lim Luigi M. Terracciano Markus H. Heim Michael N. Hall Gerhard Christofori |
| author_facet |
Fengyuan Tang Ruize Gao Beena Jeevan-Raj Christof B. Wyss Ravi K. R. Kalathur Salvatore Piscuoglio Charlotte K. Y. Ng Sravanth K. Hindupur Sandro Nuciforo Eva Dazert Thomas Bock Shuang Song David Buechel Marco F. Morini Alexander Hergovich Patrick Matthias Dae-Sik Lim Luigi M. Terracciano Markus H. Heim Michael N. Hall Gerhard Christofori |
| author_sort |
Fengyuan Tang |
| title |
LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function |
| title_short |
LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function |
| title_full |
LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function |
| title_fullStr |
LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function |
| title_full_unstemmed |
LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function |
| title_sort |
lats1 but not lats2 represses autophagy by a kinase-independent scaffold function |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/1bd4d7c4bf134f42b2b569c6511ab4d1 |
| work_keys_str_mv |
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