RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

Summary: Fragile X-related protein-1 (FXR1) gene is highly amplified in patients with ovarian cancer, and this amplification is associated with increased expression of both FXR1 mRNA and protein. FXR1 expression directly associates with the survival and proliferation of cancer cells. Surface sensing...

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Autores principales: Jasmine George, Yongsheng Li, Ishaque P. Kadamberi, Deepak Parashar, Shirng-Wern Tsaih, Prachi Gupta, Anjali Geethadevi, Changliang Chen, Chandrima Ghosh, Yunguang Sun, Sonam Mittal, Ramani Ramchandran, Hallgeir Rui, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Gustavo Leone, Janet S. Rader, Anil K. Sood, Madhusudan Dey, Sunila Pradeep, Pradeep Chaluvally-Raghavan
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
FXR1
ovarian cancer
cMYC
SUnSET
eIFs
ARE
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/1bda5605c1c8465997ff1e6038dd99f9
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https://doaj.org/article/1bda5605c1c8465997ff1e6038dd99f9

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