FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation
FBXW2 is an F-box protein that target substrates for degradation through SCF E3 ligase. Here, the authors show that FBXW2 suppresses lung cancer migration and invasion by promoting degradation of β-catenin and this is dependent on EGF-AKT1.
Enregistré dans:
| Auteurs principaux: | , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2019
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/1bdd0e3ba0f94b198831ab812a2cd975 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|